Very rare.

Association of:

-        craniofacial anomalies: dolichocephaly, high forehead, hair growing backwards, large anterior fontanel, thin eyebrows sliding towards the temples, broad nose, triangular mouth, round and small chin, cleft lip or palate (30%), large low set ears

-        variable intellectual retardation

-        growth delay

-        cardiac and renal anomalies (cystic dysplasia).

-        ligamentar hypermobility with flexion deformaties of the limbs, club foot

-        sometimes: coloboma, microphthalmos.

Anesthetic implications: 

delayed recovery from anesthesia, postooperative apneas; check renal function

References : 

-        Evans M, Lam H, Austin T.
Intravenous caffeine rescue for postoperative hypoventilation in a 16-year-old with trisomy 10: a case report.
A&A Case Reports 2017; 7: 50-1.

Updated: July 2017