MOMO syndrome
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Acronym for Macrosomia, Obesity Macrocephaly and Ocular abnormalities.
Extremely rare (1/106): a few cases reported. Syndrome of excessive growth following a de novo autosomal dominant or recessive mutation. Could be due to a mutation of the LIN00237 gene on 20p11.23 that codes for a noncoding mRNA.
Very early-onset obesity associated with mental retardation, ocular abnormalities (retinal coloboma, nystagmus), downslanting eyelids and delayed bone maturation with curvature of the femurs.
Anesthetic implications:
morbidly obese child or adolescent
References :
- Moretti-Ferreira D, Koiffmann CP, Listik M, Setian N, Wajntal A.
Macrosomia, Obesity, Macrocephaly and Ocular abnormalities (MOMO) in two unrelated patients: delineation of a newly recognized overgrowth syndrome.
Am J Med Genet 1993; 46:556-8.
- Vu PY, Toutain J, Cappellen D, Delrue M-AZ, Daoud H et al. White SM.
A homozygous balanced reciprocal translocation suggests LINC237 as a candidate gene for MOMO [Macrosomia, Obesity, Macrocephaly, Ocular abnormalities] syndrome.
Am J Med Genet part A 2012 ; 158 A : 2849-56.
- Sharda S, Panigrahi I, Marwaha RK .
MOMO syndrome with holoprosencephaly and cryptorchidism: expanding the spectrum of the new obesity syndrome.
Case reports in Genetics 2011 doi 10.1155/2011/839650.
Updated: December 2018