[MIM 157 980]

Acronym for Macrosomia, Obesity Macrocephaly and Ocular abnormalities.

Extremely rare (1/106): a few cases reported. Syndrome of excessive growth following a de novo autosomal  dominant or recessive mutation. Could be due to a mutation of the LIN00237 gene on 20p11.23 that codes for a noncoding mRNA.

Very early-onset obesity associated with mental retardation, ocular abnormalities (retinal coloboma, nystagmus),  downslanting eyelids and delayed bone maturation with curvature of the femurs.

Anesthetic implications:

morbidly obese child or adolescent

References : 

-         Moretti-Ferreira D, Koiffmann CP, Listik M, Setian N, Wajntal A. 
Macrosomia, Obesity, Macrocephaly and Ocular abnormalities (MOMO) in two unrelated patients: delineation of a newly recognized overgrowth syndrome. 
Am J Med Genet 1993; 46:556-8.

-        Vu PY, Toutain J, Cappellen D, Delrue M-AZ, Daoud H et al. White SM. 
A homozygous balanced reciprocal translocation suggests LINC237 as a candidate gene for MOMO [Macrosomia, Obesity, Macrocephaly, Ocular abnormalities] syndrome. 
Am J Med Genet part  A 2012 ; 158 A : 2849-56. 

-        Sharda S, Panigrahi I, Marwaha RK .
MOMO syndrome with holoprosencephaly and cryptorchidism: expanding the spectrum of the new obesity syndrome. 
Case reports in Genetics 2011 doi 10.1155/2011/839650.

Updated: December 2018