[MIM 154 020]

(Renal hypomagnesemia type 2, HOMG2)

Rare: < 1/106. Mg plasma concentration < 0.7 mmol/L. Autosomal dominant transmission of a mutation of the  FXYD2 gene on 11q23(locus HOMG2) which codes for the gamma subunit of the Na/K ATPase at the level of the renal tubule. The only anomaly associated with hypomagnesemia is hypocalciuria.

This condition is usually asymptomatic.

Anesthetic implications: 

monitoring of electrolytes and volemia; IV MgSO4 administration potentiates the action of the  non-depolarizing myorelaxants and has a vasodilating effect.

References : 

-         Knoers N. 
Hypomagnésémies héréditaires. 
In Actualités Néphrologiques 2000, Flammarion Médecine-Sciences, p 301-11.

Updated: March 2019