Hemoglobin H
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see thalassemias
Form of α-thalassemia with 3 defective genes causing a clinical picture of severe thalassemia. Hemoglobin H is formed by tetramers of chains β and is very unstable (hemolysis).
In the fetus, the accumulation of chains γ causes their tetramerisation to form hemoglobin Bart, the concentration of which is then higher than normal