Hemoglobin E
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See also Thalassemias
Most common hemoglobinopathy after the sickle cell disease. More prevalent in people originating from South-East Asia, where it is often associated to a thalassemia. It seems to protect against paludism. It is an abnormal hemoglobin resulting from the point mutation ß26 [B8] Glu SLys. This results in a defect in the synthesis of one of the β chain of hemoglobin.
Clinical pictures:
- heterozygous A/E: asymptomatic
- homozygous: E/E: moderate hemolytic anemia
- heterozygous E / β°: clinical picture of intermediary β-thalassemia
- heterozygous S/E: severe sickle cell syndrome
Anesthetic implications:
complete blood count, bilirubin level
References :
Updated: October 2021