Very rare. Abnormal hemoglobin due to a mutation on the β chain. This mutation causes a reduction of hemoglobin affinity for O2 and a moderate hemolytic anemia. 

Implications anesthésiques: 

complete blood count; falsely low pulse oximetry values at room air  with poor response  to increased FiO2; if in doubt, make a measurement of arterial blood gases to measure PaO2.

References : 

-         Blouquit Y, Delanoe-Garin J, Lacombe C, Arous N et al. 
Structutal study of hemoglobin Hazebrouck, β38 (C4)Thr ðPro, a new abnormal hemoglobin with instability and low oxygen affinity. 
FEBS 1984; 172: 155-8.

-         Pavy E, Haberer JP. 
Oxymétrie de pouls et hémoglobine Hasebrouk. 
Ann Fr Anesth Réanim 2014 ; 33 :53-4.

Updated: March 2019