Very rare. Abnormality of hemoglobin due to a mutation of the HBA1 gene resulting in the replacement of histidine by glutamine in position 87 on the α chain of hemoglobin . This mutation causes a change in the absorbance of light at 660 nm, the wavelength used by the pulse oximeters: SpO2 is therefore artificially low

Anesthetic implications: 

erroneously low measurement of SpO2 (pulse oximetry); monitoring by measurement of transcutaneous paO2 or the blood gases.

References:

-        Sarikonda KV, Ribeiro RS, Herrick JL, Hoyer JD.
Hemoglobin Lansing: a novel hemoglobin variant causing falsely decreased oxygen saturation by pulse oximetry.
Am J Hematol 2009; 84: 541.

Updated: August 2017