Hemoglobin Cheverly
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Very rare. Unstable hemoglobin due to the substitution of phenylalanine by serine in position 45 on the ß chain of hemoglobin
This mutation results in:
- reduced affinity of hemoglobin for O2
- decrease of the Bohr effect
- modification in the absorbance of light at the 660 nm wavelength used by the pulse oximeters: the resulting SpO2 is artificially falsely low
Anesthetic implications:
decrease of the affinity of Hbfor O2 and falsely low SpO2 value given by pulse oxymeters; monitoring either by transcutaneous PaO2 or arterial blood PaO2
References :
- Hohl RJ, Sherburne AR, Feeley JE, Huisman THJ, Burns CP.
Low pulse oximeter measured haemoglobin oxygen saturation with haemoglobin Cheverly.
Am J Hematol 1998; 59: 181-4.
Updated: July 2017