(formerly Hemoglobin Bristol)

Very rare. Congenital hemoglobin anomaly where valine is replaced by methionine in position 67 in the β chain. All cases reported to date were de novo mutations of the HBB gene (11p15). This mutation causes hemolytic anemia with splenomegaly.

Anesthetic implications:

check hemoglobin levels, frequent transfusions, risk of secondary hemochromatosis

References :

-        Hamid M, Nezhad EZ, Galehdari H et al.
A first report of hemoglobin Alesha in an Iranian patient.
Iranian Biomed J 2019; 23: 429-31.

Updated: December 2019