HAIR-AN, syndrome
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Acronym for HyperAndrogenism, Insulino-Resistance and Acanthosis Nigricans.
Cause : mutation in the tyrosine kinase domain of the insulin receptor ? One of the most frequent causes of disorders of the menstrual cycle, signs of hyperandrogenism and resistance to insulin in adolescents (prevalence 5%) and young women. It is a subset of the polycystic ovarian syndrome.
Treatment: weight loss, metformin for diabetes type 2, psychological support.
Anesthetic implications:
management of an obese patient with or without type 2 diabetes; frequent latent depression and feelings of worthlessness.
References :
Updated: April 2019