Acronym for Global developmental delay, Lung cysts, Overgrowth and Wilms tumor

Part of the spectrum of tumors caused by a mutation of the DICER1 gene (see this term).

Association of:

-        developmental delay,

-        lung cysts,.

-        excessive growth with macrocephaly

-        Wilms tumor (nephroblastoma).

-        slight facial dysmorphism: prominent forehead, large anterior fontanel, anteversed nostrils, moderate hypertelorism, moderate micrognathia.

Anesthetic Implications:

according to the type of tumor and its treatment, difficult ventilation (risk of pneumothorax ?)

References :

-        Klein S, Lee H, Ghahremani S et al.  
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.
Am J Med Genet 2014, doi: 10.1136/jmedgenet-2013-101943

Updated: April 2019