Recently described pathology. It presents as multiple pyogenic granulomas, present from birth, on the skin but also in other organs such as the brain (sometimes hemorrhagic parenchymatous lesions), liver (solid or cystic lesions), spleen (splenomegaly), muscles or, more rarely, lung or retroperitoneum (pancreas, adrenal glands). These lesions are sometimes accompanied by transient thrombopenia, anemia and hypofibrinogenemia.

Differential diagnosis: Kasabach-Merrit syndrome (kaposiform hemangioendothelioma), multiple venous malformations, cutaneo-visceral angiomatosis with thrombopenia.

Anesthetic implications:

check hemoglobin level, platelets and hemostasis In case of hepatic involvement, check the thyroid function (risk of hypothyroidism); in  case of cerebral localization, risk of cerebral hemorrhage

References : 

-        Alomari MH, Kozakewich HPW, Kerr CK, Uller W et al.
Congenital disseminated pyogenic granuloma : characterization of an aggressive multisystemic disorder.
J Pediatr 2020 ; 226 : 157-66

Updated: November 2020