[MIM 180 920]

Acronym for Aplasia of the  Lacrimal and  Salivary Glands.

Autosomal dominant transmission of a mutation in the FGF10 gene (5p12). Considered a mild form of the lacrimo-auriculo-dento-digital syndrome (see this term).

Association of:

-        hypoplasia, atresia or aplasia of the lacrimal tract: epiphora or chronic conjunctivitis

-        hypoplasia or aplasia of the parotid and submandibular glands: xerostomia, dental decay

-        hypodontia and microdontia: late tooth eruption, moderate enamel hypoplasia, small or absent lateral incisors, oral infections, dental decay

Anesthetic implications:

fragile teeth

References : 

Updated: October 2021