Dr Grand-Perret  -  mercredi 10 octobre à 12h
 

• 1984/87   PhD (anti-tumor activation of  peritoneal  macrophages, LABORATOIRE DES IMMUNOMODULATEURS, CNRS U1116, ORSAY
• 1992/95   Start-up of a drug discovery project (ELISA based HTS cellular screen) and characterisation of intra-cellular mechanisms  GLAXO, LES  ULIS RESEARCH CENTER
• 1996/2000    Study of the mode of action and discovery of the molecular target of compounds coming from a transcriptional HTS                       GLAXOWELLCOME, LES ULIS RESEARCH CENTER

• Nicodeme, E., Benoist, F., McLeod, R., Yao, Z., Scott, J., Shoulders, C. C., Grand-Perret, T.  Identification of domains in apolipoprotein B100 that confer a high requirement for the Microsomal Triglyceride Tranfer Protein. J. Biol. Chem. (1999) 274, 1986-1993.
• Issandou, M., Grand-Perret, T. Multi Drug Resistance P-glycoprotein is not involved in cholesterol esterification. Biochem. Biophys. Res. Com. (2000) 279, 369-377.
• Grand-Perret, T., Bouillot, A., Perrot, A., Commans, S., Walker, M., Issandou, M. SCAP ligands are potent lipid lowering drugs. Nature Medicine (revised manuscript submitted).

• Aspirante FNRS

• Guylène Page, Magali Peeters, Jean-Marie Maloteaux, Emmanuel Hermans.  Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. European Journal of Pharmacology 403 (2000) 75-80

• Magali Peeters, Guylène Page, Jean-Marie Maloteaux and Emmanuel Hermans.   Hypersensitivity of dopaminergic transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine. Submitted in Journal of Neurochemistry.

• Dr en sciences pharmaceutiques

• Dogne JM, Rolin S, de Leval X, Benoit P, Neven P, Delarge J, Kolh P, Damas J, David JL, Masereel B. Pharmacology of the thromboxane receptor antagonist and thromboxane synthase inhibitor BM-531. Cardiovasc Drug Rev. 2001 19(2):87-96
• Dogne JM, de Leval X, Delarge J, David JL, Masereel B. New trends in thromboxane and prostacyclin modulators.Curr Med Chem. 2000 Jun;7(6):609-28.

• Chercheur qualifié du FNRS
• Dr en sciences pharmaceutiques

•  Activation of endogeneous nitric oxide mechanisms mediate the stretch-dependency of Ca2+-release in cardiac myocytes.  Petroff, M.V., Kim, S.H., Pepe, S., Dessy, C., Perez, N.G., Marban, E., Balligand, J.L. and S.J. Sollot.   Nat Cell Biol., 10, (2001), 867-73Evidence for involvement of the PKC-alpha isoform in myogenic contractions of the  coronary microcirculation.
• Dessy, C., Matsuda,N., Hulvershorn, J., Sougnez, C.L., Sellke, F.W. and K.G. Morgan
          Am. J. Physiol., 279 (2000) H916-23 – I.F.: 2.747
• Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling.
         Dessy, C., Kelly R.A., Balligand, J.L and O. Feron.
            EMBO J., 19  (2000) 4272-80 – I.F. : 13.973

• Dr en médecine (1969), Lic. Sc. méd.(1970), Agr. Ens. Sup.(1979)
• Professeur à l'UCL (Pharmacologie) -- Chargé de Cours à l'UMH (Biochimie humaine)
• Membre du Comité Belge de Coordination de la Politique Antibiotique

• Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet. 2001 Jun 9;357(9271):1851-3.
• A public campaign for a more rational use of antibiotics.  I. Bauraind, H. Goossens, P. M. Tulkens, M. De Meyere, P. De Mol, L. Verbist. 11th European Congress of Clinical Microbiology and Infectious Disease (ECCMID), Istanbul, Turkey, 2001, Poster # 410.
• Evaluation of the Impact of a Public Campaign for a More Rational Use of Antibiotics (AB) in Belgium

41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, Ill., 2001. Session: 91 /  Antibiotic Resistance and Outbreaks.  Presentation # Late-Breaker 9.

• Dr en sciences (2000),Laboratoire de Chimie moléculaire structurale, FUNDP, Namur
• Post-doctorat à l'Université de Lausanne (Professeur B. Testa)
• Premier Assistant. Responsable des travaux pratiques de biopharmacie et de chimie thérapeutique.

•  F. Ooms, S. Delvosal, J. Wouters, F. Durant, G. Dockendolf, C. Van’t Land, T. Glass, N. Castagnoli, Jr., C. J. Van der Schyf Empirical and Molecular Modeling Study of the Pyridinium Species RHPP+, an Abundant and Potentially Neurotoxic Metabolite of Haloperidol. J. Chem. Soc., Perkin Trans 2 (2000), 1781-1787Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet. 2001 Jun 9;357(9271):1851-3.
• F. Ooms Molecular Modeling and Computer Aided Drug Design. Examples of their Applications in Medicinal Chemistry. Curr. Med. Chem. (2000), 141-158

 
• Pharmacien, doctorat en pharmacologie clinique dans le domaine de la pharmacocinétique (“Benzodiazepine Pharmacokinetics in patients suffering from Epilepsy”)
• Plusieurs années d’expérience en tant que pharmacien clinicien (essentiellement pharmacocinétique clinique)
• Directrice des études de 3e cycle à l’Ecole de Pharmacie de l’Université de Londres, y compris des programmes de spécialisation en pharmacie clinique (Director of taught Postgraduate Studie  - Course Director for the MSc/Diploma in Pharmacy Practice and the MSc in Clinical Pharmacy, International Practice and Policy)
• Consultant externe du développement de programmes de spécialisation en pharmacie clinique en Allemagne, Egypte, et Inde (External adviser on Development of Postgraduate Clinical Pharmacy Education in Germany, Egypt and India)
• Présidente des hôpitaux de Luton & Dunstable (Chairman of Luton & Dunstable Hospital NHS Trust appointed December 1999)

 

PICKRELL L., DUGGAN C., DHILLON S. (2001) From hospital admission to discharge: An exploratory study to evaluate seamless care.
Pharmaceutical Journal 267: 650-653.

DHILLON S. (2001) Do Clinical Pharmacists really improve the quality of patient Care?
Hospital Pharmacist 8: 118.

DUGGAN C., JOSHUA A., DHILLON S. (2001) What part should Pharmacists play in medicines related information?
Pharmaceutical Journal 266: 364-366.

MANGUES A.M. and DHILLON S. (2000) A British-Spanish Collaboration in Clinical Pharmacy Teaching.
Pharmacy Education 1:55-58.

DHILLON S., DUGGAN C., PEARSELL K., WADE P., PATEL P. (2000) An evaluation of interventions of "major significance" in North Thames Region.
Continuing Professional Development Pharmacy 1: 12-19.

DUGGAN C., DHILLON S., BATES I. (1999) Developing Postgraduate Education to meet the Needs of the Profession.
Pharmaceutical Journal 263: 949.

DHILLON S. and FERGUSON M. (1999) A survey of adverse drug reaction reporting by hospital pharmacists to the Committee on Safety of Medicines - the role of pharmacy departments.
International Journal of Pharmacy Practice 7: 167-171.
 

Pr Soraya DHILLON
Centre for Practice and Policy
University of London

• 1988: Licence Spéciale en Sciences Naturelles Appliquées (UCL, Prof. Charles Colson)
• 1991: Doctorat en Sciences Naturelles Appliquées à (UCL/ICP, Prof. Guy Cornelis)
• 1992-1995: Séjour post-doctoral à State University of New York at Stony Brook (Dr. Jorge Galan)
• 1995-1998: Group Leader à Megan Health, Inc., St Louis, Missouri (development de vaccins vivants)
• 2000- : Senior Scientist à Theravance Inc. (formely Advanced Medicine, Inc.) à South San Francisco, Cal. (dévelopment de nouveaux antibiotiques contre les organismes resistant aux traitements actuels).

• Multivalent-drug binding:
• D. Wright and L. Usher (2001) Multivalent Binding in the Design of Bioactive Compounds.  Current Organic Chemistry,  5, 1107-1131
  (full paper as PDF file)
  
  
• résistance aux glycopeptides
• Gholizadeh Y, Courvalin P. Acquired and intrinsic glycopeptide resistance in enterococci. Int J Antimicrob Agents. 2000 Nov;16 Suppl 1:S11-7. Review. PMID: 11137403
• Leclercq R, Courvalin P. Resistance to glycopeptides in enterococci. Clin Infect Dis. 1997 Apr;24(4):545-54; PMID: 9145724
• Arthur M, Reynolds P, Courvalin P. Glycopeptide resistance in enterococci. Trends Microbiol. 1996 Oct;4(10):401-7. Review.
• PMID: 8899966 Arthur M, Reynolds PE, Depardieu F, Evers S, Dutka-Malen S, Quintiliani R Jr, Courvalin P. Mechanisms of glycopeptide resistance in enterococci. J Infect. 1996 Jan;32(1):11-6. Review. PMID: 8852545

• Chen LM, Kaniga K, Galan JE. Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol. 1996 Sep;21(5):1101-15.
• Kaniga K, Bossio JC, Galan JE. The Salmonella typhimurium invasion genes invF and invG encode homologues of the
• AraC and PulD family of proteins. Mol Microbiol. 1994 Aug;13(4):555-68.
• Kaniga K, Delor I, Cornelis GR.  A wide-host-range suicide vector for improving reverse genetics in gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica. Gene. 1991 Dec 20;109(1):137-41.

• Prof. C BRUNET , professeur de pharmacologie , vice-doyen de la faculté de pharmacie de LILLE et praticien hospitalier spécialité pharmacie au Centre Hospitalier de LOOS;
• Prof. M. LUYCKX, professeur de pharmacie clinique à la faculté de pharmacie de LILLE, praticien hospitalier spécialité pharmacie au CH de DENAIN;
• Prof. L Dubreuil, profeseur de microbiologie clinique assesseur du Doyen  à la faculté de Pharmacie de Lille, consultant au service régional Uniersitaire des Maladies infectieuses et du voyageur, Hopital Dron à Tourcoing, Bactériologiste, spécialiste des bactéries anaérobies strictes

• cursus de l'étudiant français en pharmacie hospitalière et en biologie,
• enseignements orientés vers la pharmacie clinique,
• dossiers et examens dans cette discipline.