Université Catholique de Louvain (UCL-Bruxelles)
Programme des Séminaires et Conférences du
Louvain Drug Research Institute et de l'Ecole doctorale en sciences pharmaceutiques
Année académique 2011-2012

Prof. A. Dalhoff
University of Kiel, Kiel, Germany

From structure/activity relationships via multitargeting to networking

Dr.G. Reychler
Kinésithérapie respiratoire, cliniques Universitaires St luc, UCL

Comment améliorer la déposition pulmonaire des médicaments ?

Publications en relation avec l'exposé

• Roche and Huchon. Rationale for the choice of an aerosol delivery system. J Aerosol Med. 2000;13(4):393-404. Review
• Lo Valvo et al. Inhalation therapy in asthmatic and not asthmatic children. Int J Immunopathol Pharmacol. 2011 Oct;24(4 Suppl):61-7. Review
• Rubin. Pediatric aerosol therapy: new devices and new drugs. Respir Care. 2011 Sep;56(9):1411-21; discussion 1421-3. Review

info : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>

Dr. P. Levêque
Biomedical Magnetic Resonance, LDRI

La Résonance Paramagnétique Electronique (RPE) en sciences biomédicales: curiosité technologique ou instrument de routine? Stratégies de détection pour radicaux stables et instables en imagerie et en spectrométrie RPE.

Dr. L. Mespouille
Laboratory of Polymeric and Composite Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), Université de Mons

Implication de la chimie des polymères dans l’élaboration de biomatériaux à usage médical

Publications en relation avec l'exposé

• Bartolini et al, Guanidine-based polycarbonate hydrogels: from metal-free ring-opening polymerization to reversible self-assembling properties. Soft Matter, 2011, 7, 9628
• Mespouille et al. Expanding the role of chemistry to produce new amphiphilic polymer (co)networks. Soft Matter, 2009, 5, 4878–4892
• Mespouille et al. Novel Biodegradable Adaptive Hydrogels: Controlled Synthesis and Full Characterization of the Amphiphilic Co-Networks. Chem. Eur. J. 2008, 14, 6369 – 6378

info : V. Préat 02.764.73.78 <veronique.preat@uclouvain.be>

publications en relation avec l'exposé:

• Marquez et al. Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin. PLoS ONE 2011, 6:e28368
• Vallet et al. Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin. Toxicology 2011, 290:179-187
• Vallet et al. Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin, and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages.
  International journal of Antimicrobial Agents 2011, 38:249-256.

Promoteur : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>

Prof. Murali C. Krishna
Radiation Biology Branch, National Cancer Institute, Bethesda, USA

Applications of EPR and MRI in evaluating treatment response in tumor bearing mice

Prof. P. Cani
Nutrition et Métabolisme, LDRI

Gut microbiota, obesity and diabetes: a matter of inner life

publications en relation avec l'exposé

• Everard et al. Responses of gut microbiota, glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011 in press
• Delzenne et al. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nature Rev. Endocrinol. 2011 Aug 9. doi: 10.1038/nrendo.2011.126. [Epub ahead of print]
• Cani PD, Delzenne NM. The gut microbiome as therapeutic target. Pharmacol Ther. 2011;130:202-12

Dr G. Bommer,
Institut de Duve BCHM/GRM

miRNAs as regulators in lipid metabolism and cancer

publications en relation avec l'exposé

• Bommer & MacDougald. Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus. Cell Metabolism. 2011 Mar 2;13(3):241-7
• Gerin et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Journal of Biological Chemistry. 2010 Oct 29;285(44):33652-61.

Dr F. Musuamba,
Louvain Centre for Toxicology and Applied Pharmacology

Towards better designed studies for more relevant results: Application to clinical research on immunosuppressive drugs

publications en relation avec l'exposé

• Musuamba et al. Limited sampling models and Bayesian estimation for mycophenolic acid area under the curve prediction in stable renal transplant patients co-medicated with ciclosporin or sirolimus. Clin Pharmacokinet. 2009;48(11):745-58
• Musuamba et al. Time of drug administration, CYP3A5 and ABCB1 genotypes, and analytical method influence tacrolimus pharmacokinetics: a population pharmacokinetic study.Ther Drug Monit. 2009 Dec;31(6):734-42

Dr S. Vincent,
Laboratoire de Chimie Bio-Organique
FUNDP – Faculté des Sciences

Novel strategies for the development of antibacterial agents : antivirulence and carbohydrate processing proteins

publications en relation avec l'exposé

• Durka et al. The Functional Valency of Dodecamannosylated Fullerenes with Escherichia coli FimH – Towards Novel Bacterial Antiadhesives. Chem. Commun. 2011, 47, 1321-3
• Dohi et al. Stereoselective glycal fluorophosphorylation: Synthesis of ADP-2-fluoro-heptose, an inhibitor of the LPS Biosynthesis. Chemistry. 2008, 14, 9530-39.

Dr G. Labar,
Chimie pharmaceutique
LDRI

New inhibitors of endocannabinoid hydrolases around the benzotriazol-1-yl carboxamide scaffold

publications en relation avec l'exposé:

• Labar et al. A review on the monoacylglycerol lipase: at the interface between fat and endocannabinoid signalling. Curr Med Chem. 2010;17:2588-607.
• Labar et al. Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. Chembiochem. 2010;11:218-27.
• Bertrand et al. Structural basis for human monoglyceride lipase inhibition.. J Mol Biol. 2010;396:663-73.

info : M.P. Mingeot-Leclercq 02.764.73.74 <marie-paule.mingeot@uclouvain.be>

publications en relation avec l'exposé:

• Pachikian et al. Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition. BMC Physiol. 2008 Dec 1;8:21
• Pachikian et al. Changes in Intestinal Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice. Journal of Nutrition 2010; 140( 3): 509-514

• Pachikian et al. Hepatic n-3 Polyunsaturated Fatty Acid Depletion Promotes Steatosis and Insulin Resistance in Mice: Genomic Analysis of Cellular Targets. PLoS One. 2011;6(8):e23365.

• Pachikian et al. Involvement of gut microbial fermentation in the metabolic alterations occurring in n-3 polyunsaturated fatty acids-depleted mice. Nutr Metab (Lond). 2011 Jun 27;8(1):44.

info : N. Delzenne 02.764.73.67 <nathalie.delzenne@uclouvain.be>

Dr C. Govaerts,
Department of Structure and Function of Biological Membranes, Structural Biology and Bioinformatics Center, Université Libre de Bruxelles

Towards of cure for Cystic Fibrosis : Restoring mutant CFTR Function with Nanobodies

Dr P. Fernandes,
CEO, Cempra Pharmaceuticals, Chapel Hill, NY

Solithromycin- A ketolide worth waiting for

publications en relation avec l'exposé

• Llano-Sotelo et al. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother. 2010; 54:4961-70
• Woosley et al. CEM-101 activity against Gram-positive organisms. Antimicrob Agents Chemother. 2010;54:2182-7
• Still et al. Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects. Antimicrob Agents Chemother. 2011;55:1997-2003.

Breakfast at 8.15 am. registration required before Monday 21, noon time

Dr S. Lemaire,
Pharmacologie cellulaire et moléculaire, LDRI

Factors influencing the activity of antibiotics towards intracellular forms of Staphylococcus aureus

publications en relation avec l'exposé

• Lemaire S et al, Contrasting effect of acidic pH on the extracellular and intracellular activity of anti-Gram-positive fluoroquinolones (moxifloxacin and delafloxacin) against Staphylococcus aureus. Antimicrob Agents Chemother [2011], 55:649-58
• Lemaire S et al, Role of Acidic pH in the Susceptibility of Intraphagocytic Methicillin-Resistant Staphylococcus aureus Strains to Meropenem and Cloxacillin. Antimicrob Agents Chemother. [2007], 51:1627-32
• Lemaire S et al, Restoration of susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics by acidic pH: role of penicillin-binding-protein 2A (PBP 2A. )J Biol Chem. [2008], 283:12769-76
  

info : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>

publications en relation avec l'exposé:

• Matuszak et al. Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth. Eur J Pharm Sci. 2011 Nov 23.
• Matuczak et al. Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: Investigation of the target residues and comparison with octhilinone. Bioorg Med Chem Lett. 2011 ;21(24):7321-4
• Matuszak et al. Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 ; 52(23):7410-20

info : D. Lambert <didier.lambert@uclouvain.be>

Prof. R. Verbeeck
Pharmacokinetics & Drug Metabolism, LDRI

Pharmacokinetics in the elderly: the development and evaluation of new medicines

Dr B. Portet & C. Lubrano
Centre de Recherche YVES ROCHER, Issy-les Moulineaux Cedex, France

Deux exemples de developpement d'actifs végétaux cosmétiques : de la filière à l'industrialisation

Prof. J.M. Dogné
Departement de Pharmacie, FUNDP

Pharmacovigilance: le cas de la dompéridone

Bridging the gap between tumor hypoxia and tumor response: Access the value of imaging biomarkers and the effect of dose escalation

Dr A. Neyrinck
Metabolism and Nutrition Research Group, LDRI

Cibler le microbiote intestinal dans la gestion de l'obésité: intérêt des arabinoxylo(oligo) saccharides de blé

publications en relation avec l'exposé

• Neyrinck et al. Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice. Nutrition and Diabetes 2; doi:10.1038/nutd.2011.24 (2012)
• Neyrinck et al. Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, roseburia and bacteroides/prevotella in diet-induced obese mice. PLoS One, 6, e20944 (2011)
• Neyrinck & Delzenne. Potential interest of gut microbial changes induced by non-digestible carbohydrates of wheat in the management of obesity and related disorders. Curr Opin Clin Nutr Metab Care; 13(6):722-728 (2010)

Dr F. Musuamba,
Louvain Centre for Toxicology and Applied Pharmacology

Pharmacokinetic/pharmacodynamic modelling and simulations for dose selection and adjustment in drug development and clinical settings (research seminar)

Nouveaux anticoagulants dans la fibrillation auriculaire : rôle du pharmacien (lesson)

info : V. Préat 02.764.73.78 <veronique.preat@uclouvain.be>

Dr H. Rahimtoola,
The Netherlands

Pharmaceutical care intervention in preventing medicine related hospital admissions (research seminar)

Nouveaux anticoagulants dans la fibrillation auriculaire : rôle du pharmacien (lesson)

info : V. Préat 02.764.73.78 <veronique.preat@uclouvain.be>

Pharm. F. Mullier
Namur Thrombosis and Hemostasis Center, FUNDP et CHU Mont Godinne

Biological microvesicles: New players in hemostasis and thrombosis

Dr B. Portet
Centre de Recherche YVES ROCHER, Issy-les Moulineaux Cedex, France

Un exemple de développement d'actifs végétaux cosmétiques : de la filière à l'industrialisation

Prof. P. Cornelis
Research Group Microbiology, VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels

Phenotypic and molecular characterization of a Pseudomonas aeruginosa small colony variant resistant to aminoglycosides

publication en relation avec l'exposé

• Wei et al. Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa. PloSone 2011;6(12):e29276

publications en relation avec l'exposé:

• Delattre et al. Empirical models for dosage optimization of four beta-lactams in critically ill septic patients based on therapeutic drug monitoring of amikacin. Clin Biochem. 2010;43(6):589-98.
• Delattre et al. Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients. Ther Drug Monit. 2010;32(6):749-56.

info : P. Wallemacq 02.764.67.20 <pierre.wallemacq@uclouvain.be>

M. Dubuisson
Conseiller technologique Biotech Santé
MIRVAL - Académie Louvain
ADRE, UCL

Le chercheur face à la propriété intellectuelle et à la valorisation de ses résultats: que faut-il absolument savoir?

Dr. P. Levêque
Biomedical Magnetic Resonance, LDRI

La Résonance Paramagnétique Electronique (RPE) en sciences biomédicales: curiosité technologique ou instrument de routine? Stratégies de détection pour radicaux stables et instables en imagerie et en spectrométrie RPE.

Dr J. Verrax
Toxicology and Cancer Biology, LDRI

Nrf2 signaling: When cancer cells hijack an antioxidant pathway to improve their resistance to chemotherapy

publications en relation avec l'exposé

DeNicola et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011;475(7354):106-9.

Dr M. Riou
Plate-Forme d’Infectiologie Expérimentale, INRA, Tours, France

La plateforme d'infectiologie du centre INRA de Tours : une animalerie protégée pour "modèles animaux en infectiologie" à dimension européenne

publications en relation avec l'exposé:

• Hamtiaux et al. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer. 2012 ;12(1):92.
  
• Hamtiaux et al. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS One. 2011;6(10):e26823
  

Promoteurs : D. Lambert 02.764.73.63 <didier.lambert@uclouvain.be> & B. Gallez 02.764.73.91 <bernard.gallez@uclouvain.be>

Prof. A. Petitjean
Department of Chemistry, Queen's University, Kingston ON,
Canada

Shape Matters: Controlling the shape of artificial molecules for Biological Applications