To cover some major new developments in immunology through the analysis of experimental results.
Main themes
Illustrate some aspects of modern immunology through experimental observation and analysis. For each topic: a brief reminder of basic concepts followed by the analysis of important experiments and the description of the resulting new concepts
Content and teaching methods
HLA molecules: structure, serological and molecular typing, transplantation.
Antigen processing for HLA class I and class II molecules.
Monoclonal antibodies, principles, humanization, examples of new drugs.
Innate immunity: NK cells, inhibitory receptors, viral escape mechanisms.
Toll-like receptors and ligands.
Regulatory or suppressor T cells.
Cytokines and their receptors, signal transduction mechanisms.
Anti-viral immunity and viral escape mechanisms.
Anti-tumor immunity and cancer vaccines.
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)
Lecturing by several senior investigators.
Evaluation through a personal essay based on a scientific paper selected with the coordinator.